Dr. Mathilde Krim, a wealthy, straight, scientific researcher who devoted her life to fighting HIV/AIDS, died on Monday (January 15, 2018) at her home in Kings Point, N.Y. at the age of 91.
“The board of trustees and staff of amfAR mourn the passing of our beloved Founding Chairman, Mathilde Krim, Ph.D. A pioneer in AIDS research and activism, Dr. Krim was at the forefront of scientific and philanthropic responses to HIV/AIDS long before the world fully understood its catastrophic global reach,” reads amfAR’s statement issued Tuesday morning.
“As amfAR’s founding chairman, and chairman of the board from 1990 to 2004, she was the heart and soul of the organization. She helped create it, supported it, kept it afloat more than once, and guided it with extraordinary dedication. She testified on Capitol Hill on several occasions, and was a driving force behind legislation that expanded access to lifesaving treatment and behind efforts to scale up federal funding for AIDS research. In August 2000, she was awarded the Presidential Medal of Freedom – the highest civilian honor in the United States,” the statement continued.
“Dr. Krim had such a profound impact on the lives of so many. While we all feel a penetrating sadness at the loss of someone we loved so deeply, it is important to remember how much she gave us and the millions for whom she dedicated her life. There is joy to be found in knowing that so many people alive today literally owe their lives to this great woman,” amfAR concluded.
New York-based Gay USA co-host and co-producer Andy Humm and longtime AIDS activist Peter Staley were the first to note Krim’s passing on their Facebook pages Monday night.
“My greatest AIDS hero died a few hours ago,” Staley wrote. “Dr. Mathilde Krim, founder of amfAR, warrior against homophobia and AIDS-related stigma, dedicated defender of science and public health, and mother-figure and mentor to countless activists, will leave a deep hole in the continued fight against AIDS — a fight she dedicated her life to. She was 91.”
“All honor to the great Dr. Mathilde Krim, founder of AmFAR (started as the AIDS Medical Foundation in 1983), who died today at 91–a giant in the fight against HIV and AIDS bringing both scientific and fundraising savvy and celebrities to the cause in the worst years of the AIDS pandemic. A tireless brilliant, calm, steady voice for healing, research, compassion and justice. Millions owe her their lives,” Humm wrote.
Krim’s passion to help people with AIDS was fueled by seeing newsreel footage as a teenager of the Nazi Holocaust during World War II. “What it did was to sensitize me against injustice. It’s really basically that—cruelty and injustice. And it’s a theme in my life,” Krim said in a 1990 interview.
”I volunteered for the [AIDS Medical Foundation] because I was incensed!” Krim said in a Nov. 1984 interview with the New York Times in her interferon laboratory at Sloan-Kettering Institute for Cancer Research, promoting the foundation’s first fundraiser—dinner and a fashion show headlined as Fashion Affair ’84. ”So many young men were dying, mostly intelligent and sophisticated young men, some of the city’s best products. And many would be dying abandoned or alone because they were afraid to contact their families.”
Krim’s life reads like a movie script with multiple odd juxtapositions—fashion, science, young gay men dying of AIDS while also being a “traditional wife” of a Hollywood studio head.
Krim was born Mathilde Galland in Cuomo, Italy in 1926. Her Swiss father was an agronomist and her mother, who was of Austrian descent, had grown up in Czechoslovakia. Her father moved the family to Geneva, Switzerland when she was 6.
As World War II started to break out in Europe, Krim heard stories about “sinister-sounding people called the Jews.”
At one point one summer, Krim worked as a gopher in the office of a lawyer who represented the United Jewish Appeal in Geneva. She saw the influx of Jewish refugees seeking asylum in Switzerland, only to be scoffed at and turned over to the Nazi-aligned Vichy French if they had no bank accounts.
“It made me sick. I was 16, 17, you know; one is impressionable. I was indignant. I decided, ‘Oh, no, I`m not going to live in a country that does this,’” she told an interviewer in 1990.
The epiphany came one day when she saw newsreel footage about the liberation of the Nazi concentration camps. “I went home and cried and told my parents. They said, ‘Oh, it may be exaggerated; it may not all be true.’ I kept crying; I was in a state of shock. And that lasted several days. To be young and to be unprepared for something like that-it was a terrible psychological shock,” Krim said. “I had never ever seen somebody die or dead, you know, and there I see human bones-most horrible pictures-being dumped from a truck into a hole in the ground, and this kind of thing.”
”I grew up not really knowing what was going on in the camps,” Krim said in 1988, ”though I knew that there was a good deal of anti-Semitism in Europe. My parents were no worse than the others, but they were like the others.”
But the “idea that people of my society were responsible for what had happened—it was very shocking to me. And I became very interested in knowing who were those Jews whom everybody had been after. Because I heard those terrible stories, that they were exploiting others, and I wanted to see for myself.”
In 1945, Krim went to the University of Geneva and met Jews from British-controlled Palestine. ”They were totally different from what I was told,” she said. ”I thought, ‘My God, if anything, I want to be like them.’ ”
Mathilde converted to Judaism and started working with a militant anti-British underground movement called the Irgun, run by a radical Zionist named Menachem Begin. Mathilde helped smuggle weapons to Begin from old French Resistance sympathizers. (When Begin became Israeli prime minister years later, he would be Krim’s houseguest.)
During this time, Krim studied biology in Geneva and, in 1953, received her Ph.D. She also fell in love with fellow Jewish radical David Danon and took his medical courses when he was away. The couple married and moved to Israel in early 1953. “We were in perfect harmony as long as the world was against us. But as soon as the pressure was off, we divorced,” she said
Krim became a junior researcher at the Weizmann Institute of Science and in 1956 was asked to give a tour to a honcho on the institute’s board of directors—New York movie executive Arthur Krim. They married in 1958 and moved to New York. Krim’s 7-year old daughter Daphna adjusted better than her mother. But eventually, Krim found a job at Cornell University Medical School where she studied virology, with the added benefit of being able to speak German, French, Italian, English, Hebrew and ”some Spanish.”
In 1962, Krim transferred to Sloan Kettering to pursue research into whether cancer might be caused by viruses. Her lawyer husband Arthur Krim, meanwhile, became chair of Orion Pictures and a prominent Democratic fundraiser and senior advisor to three Presidents—John F. Kennedy, Lyndon B. Johnson and Jimmy Carter. Mathilde Krim was the gracious hostess in their art-filled townhouse on East 69th Street when a president or presidential contenders such as Walter Mondale held court or stayed over.
Her husband was also a big fan of Democrat intellectual Adlai Stevenson, which spurred the couple’s interest in the civil rights movement in the US and Africa. With her passion to fight injustice, Krim became a member of the Congress on Racial Equality (CORE) and in 1966, joined the National Urban League. Meanwhile, from 1966 to 1968, Arthur Krim served as chair of the Democratic National Finance Committee.
By 1970, while writing a research report for a panel studying the history of cancer—a report that played a significant role in passage the National Cancer Act of 1971—Krim discovered an account of interferon, “a naturally occurring protein that seemed to ‘interfere’ with viruses, including those that caused tumors. Some experiments even indicated that interferon was effective against the tumors themselves,” according to the New York Times.
Krim was hooked on the possibility that interferon could lead to a more humane biological treatment for cancer, though other researchers were considerably less impressed, calling it ”imaginon,” accusing her of letting her heart rule her head. She was soon dubbed the Interferon Queen—a nicknamed she earned, using guile to get funding from the National Cancer Institute after being turned down. In 1975, she convinced the institute to sponsor an international conference on interferon and the night before she and her Hollywood-connected husband threw a party for 100 at their swank Manhattan townhouse.
”She more or less singlehandedly rescued the field from oblivion,” Martin S. Hirsch, an interferon expert at Massachusetts General Hospital, told the New York Times.
The institute gave her funding, as did the American Cancer Society, and by 1981, Krim had $6 million for her research, in addition to what she could raise from outside foundations and donors. Though touted as a possible cancer breakthrough, the research initially yielded mostly disappointments, treating only a rare form of leukemia. Her reputation as a detached scientist was questioned.
‘I probably could have done more if I had a husband less involved in things,” Krim told The New York Times in 1984. “Research is such a competitive life, and most of my colleagues are men who have wives who do everything at home. I know if I have to give a dinner for 100 people and be all dressed up and have my hair done, I can’t concentrate completely on my work.”
But in 1980, Krim’s attention was diverted by mysterious symptoms impacting patients of her research colleague, Dr. Joseph Sonnabend, who practiced medicine in Greenwich Village. Gay men were coming to him with enlarged lymph nodes, enlarged spleens and infections that failed to respond to treatment—and they had seriously compromised immune systems.
“Clearly, it was a biological infectious agent that was causing this disease and we also concluded that it must be sexually transmissible. My friend started using his medical practice as a source of clinical (blood) samples; he would send them around to experts to try to find another link, but nobody would figure out anything,” Krim later recalled. “In the spring of `81 Dr. Sonnabend came to tell us that some of his patients were dying, and our research activities were intensified.”
By then, Krim was the director of the interferon laboratory at Sloan-Kettering. “It was totally mind-blowing for a scientist who thinks she knows something to realize that, here in the middle of New York in the 20th century, a new disease could occur,” Krim said. “I personally didn’t believe for a minute that being gay could cause it. It was a scientific and medical puzzle that attracted my attention.”
Krim and Sonnabend worried that the mysterious disease was spreading but no one seemed to listen. The disease was killing those who “deserved it.”
Though her husband had gay friends, Krim told POZ Magazine, “I knew nothing about the gay community in 1981. Dr. Joseph Sonnabend sent me his patients, including Michael Callen, who told me what gay life was. That was quite an education! I was disgusted by the way society accused gay men of having created something terrible. When you think of it, the promiscuous life was caused by society—it didn’t allow gay men to get married or to have honest relationships. They had to hide.”
Krim’s compassion and hatred of injustice set in.
“In those early days, they were literally dying in the streets,” Krim told the Los Angeles Times in 2000. “[Gay men who had AIDS] lost their jobs, their apartments–their families turned away from them. It turned my stomach, it really impacted me and I decided this was something not to be tolerated.”
Unable to raise funding for their research, the colleagues decided to start their own organization in June 1983. The AIDS Medical Foundation (AMF) was co-founded by Krim—then 57 years old—Sonnabend, Nobel-prize winning scientist Dr. David Baltimore, singer, Sonnabend patient and AIDS activist Michael Callen (co-founder with fellow Sonnabend patient Richard Berkowitz of the People with AIDS Coalition), and respected philanthropist Mary Lasker.
The foundation was created to serve as a “scientific venture capitalist” to give provide seed money to researchers and scientists with promising AIDS-related projects that had been turned down for government grants. They wanted to be the AIDS version of the American Cancer Society. Arthur Krim kicked in the first $100,000 and within 90 days, Mathilde Krim had raised an additional $550,000. She also continued her interferon research, oversaw AMF operations, visited hospitals and clinics, and hosted fundraisers. Nothing was easy with efforts hampered by stigma. The AIDS Medical Foundation could not even list its full name in the lobby index in the Helmsley Building at 230 Park Avenue, having to list its office as A.M. Foundation.
Working together wasn’t easy, either. When Callen and Berkowitz wrote the first risk-reduction pamphlet under Sonnabend’s oversight entitled “How to Have Sex in an Epidenic: One Approach” espousing condom use, they approached Krim about publishing the safe sex guide through AMF. However, POZ founder Sean Strub writes in his book Body Counts, “Krim balked, fearing the frank language about anal sex was too risqué and would turn off potential donors. She did agree to let the foundation serve as a fiscal pass-through, so donations to print it would be tax-deductible.”
It was a serious concern, with donors from large corporations and Wall Street investment houses buying into the mythology of homosexuality.
”They felt that this was a disease that resulted from a sleazy life style, drugs or kinky sex—that certain people had learned their lesson and it served them right,” Krim told the New York Times in 1988.
”That was the attitude, even on the part of respectable foundations that are supposed to be concerned about human welfare.”
It sounded like the anti-Semitic propaganda she heard about Jews from the Nazis and Nazi sympathizers. ”I thought we had to enlarge our board and diversify—load it with straight people so that it’s not one more gay organization,” she said. To that end, she brought on board Elizabeth Kummerfeld, whose husband, Donald D. Kummerfeld, was president of Magazine Publishers of America. They set about planning for a $150-a-ticket November 1984 fashion show at the Tower Gallery, 45 West 18th Street, for which 50 designers, including Pauline Trigere, Bill Blass, Zandra Rhodes, Adolfo, Galanos and Calvin Klein, and other designers agreed to donate dresses and gowns. The show as narrated by Arlene Francis, followed by an auction and a buffet planned by Craig Claiborne. Former First Lady Rosalynn Carter, a friend of the Krims, attended.
Funding for Sonnabend’s research and perhaps a clinic was imperative. “We need such a clinic,” Krim told the New York Times in 1984, ”because it’s a place where patients can come without fear of discrimination. We deal with a population afraid of discriminatory practices, and that is not only gay men but drug users as well.”
The AIDS situation as ”very worrisome,” she continued. ”It’s not going to remain in the high- risk groups. All the evidence shows the disease is spreading in all directions, but people just aren’t worried anymore.”
At the same time, on the other side of the country in Los Angeles, pioneering AIDS researcher and immunologist Dr. Michael Gottlieb, was working with actress Elizabeth Taylor to create a foundation using $250,000 in start-up funding contributed by the late actor Rock Hudson, close friend of Taylor’s and a patient of Gottlieb’s. Krim called them about joining their efforts in the summer of 1985.
“Elizabeth Taylor and others were forming a like-minded organization on the West Coast, and I went out to visit her. She invited me to her house, and was immediately interested in working together, so we joined our organizations to form the American Foundation for AIDS Research,” Krim said in a 2015 interview. “From then on, Elizabeth dedicated herself to doing public speaking and even testifying in front of Congress.”
‘It was a shotgun marriage,” Gottlieb told Vanity Fair in 1992, a marriage of necessity between science and show business.
“It did occur to me that having AmFAR on the East and West coasts might dilute it,” Taylor said. “Then I realized that Mathilde is a very powerful lady with a background that couldn’t have been more suitable. So it seemed like a very large and powerful decision.”
Mathilde Krim is “a smart woman and one of the most powerful I’ve ever met,” says Bill Misenhimer, who became amFAR’s first executive director, told the magazine. “You don’t fight her because she always wins. And AIDS is her life.”
“We complement each other very well,” Krim told VF, shrugging off questions about clashes. “I have a professional education in biology and medicine, and because I’m not a public figure I can work at the desk long hours. I mind the shop. Elizabeth contributes to projecting an image of the organization. She deals with the public very well.”
That was a quick lesson learned for the new national organization when Taylor appeared at the second amFAR fashion show in 1985 in Jacob K. Javits Convention Center in New York City. “We’d dutifully set in place security protection, but we didn’t make sufficient arrangements,” Krim recalled. “We didn’t realize she’d be mobbed by the crowd. She was atop a staircase with all the paparazzi and the public pushing behind—they almost threw her down.”
While Krim was gaining momentum with AMF, she was being unfavorably scrutinized at Sloan-Kettering by new president Paul A. Marks.
”I was told very clearly that I should tone down my visibility,” Krim told the NYT in 1988. ”He didn’t want his institute to become known as an AIDS hospital. Bad blood developed and at one point I decided, ‘This is enough.’”
(A spokesperson told the NYT that Sloan-Kettering continued to contribute to research on AIDS and interferon therapy.)
Krim left Sloan-Kettering in 1985 and subsequently became an associate research scientist at St. Luke’s-Roosevelt. But she was finished as a research scientist. In 2000, the Los Angeles Times noted that her besmirched, dogged research into interferon were vindicated: “Interferon has proved effective in inducing remissions in hairy-cell leukemia, and now is used to treat a long list of serious maladies: bladder cancer, renal cell cancer, hepatitis C, malignant melanoma, multiple myeloma, non-Hodgkin’s lymphoma and Kaposi’s sarcoma.”
Serving as AmFAR’s board chair suited her. ”I came to the conclusion that it’s better if I stay on the outside and help people inside the labs,” she said. ”I’m not such a genius that somebody else cannot do what I was doing. And these would be people who cannot do what I can.”
But Krim was able to use that scientific knowledge to challenge important issues that others took as fact. One of the most critical examples was in 1986—before ACT UP—when she took on the medical establishment over the testing of AZT. Per protocol, half the test subjects were given placebos, which Krim concluded would mean the placebo group could possible die by the time the effectiveness of the drug was determined. Though not a cure and saddled with harmful side effects, at least AZT could extend the dying person’s life for a few months.
”People who are on their last legs should get anything they want,” she said. ”We should just make sure we’re not killing them with it.”
Krim testfied before Congress that she opposed placebos in “double-blind” drug trials for people with full-blown AIDS. She lost out to two powerful opponents—National Cancer Institute top AIDS drug expert Samuel Broder and NIH AIDS research coordinator Anthony S. Fauci. But she eventually helped convince the NIH two years later to stop using placebos and to use AZT as the control instead. Additionally, Broder joined AmFAR’s scientific advisory committee, helping determine who gets grants.
One of amFAR’s biggest nights was the appearance of President Ronald Reagan, who had been invited by Taylor to speak at the benefit where Surgeon General Koop was among the honorees. It was Reagan’s second term in office and he had not yet addressed the AIDS epidemic. The benefit was the night before the third international conference on AIDS in Washington.
”He and his advisers must have thought that this was a good opportunity to appear in public in front of people who would behave reasonably well,” Krim told the New York Times in 1988.
A Presidential speechwriter talked to AmFAR’s president Mervyn F. Silverman, who suggested that Reagan stress compassion and avoid the controversial systematic testing for the AIDS virus.
”The President said some of the right things, but he chose to mention testing,” Krim said. ”So that was the undoing of the rest of his speech. Even in our audience some people resented it, and he was in fact hissed, which was not the polite thing to do. But he should have known better.”
In fact, that May 31, 1987 speech contained harsh words reflective of his religious right domestic policy base. As of April 1987, the Centers for Disease Control reported 33,997 cases of AIDS in the US, with 19,658 deaths, no cure and the pall of stigma hanging over the country.
“If a person has reason to believe that he or she may be a carrier, that person has a moral duty to be tested for AIDS; human decency requires it. And the reason is very simple: Innocent people are being infected by this virus, and some of them are going to acquire AIDS and die,” Reagan said. “I’ve asked the Department of Health and Human Services to determine as soon as possible the extent to which the AIDS virus has penetrated our society and to predict its future dimensions.”
He said the AIDS immigration ban, testing for all federal prisoners, and possibly testing of veterans, “in addition to the testing already underway in our military and foreign service.”
“[Reagan’s speechwriters] didn’t know anything about AIDS, so we wrote the first half of the speech, where Reagan talked about compassion, justice, care — all the right things,” Krim told Vanity Fair. “We asked them to please not talk about mandatory testing, because it was not recommended scientifically, legally, or medically. We said it would elicit a furious reaction from the public. But one of Reagan’s advisers revised the speech and put it in.”
“The president mentioned mandatory testing and people jumped out of their seats. Then they started heckling him, so I jumped up and said, ‘Don’t be rude. This is your president and he is our guest,’” Taylor told the magazine.
Krim stuck with amFar until 2005 when she stepped down as founding chair, having helped build the organization into a prominent private supporter of AIDS research. Michael Musto wrote in POZ magazine, “As Dr. Mathilde Krim ‘a.k.a. the Mother of AIDS advocacy’ passes the amfAR torch to classy designer Kenneth Cole, her once-great institution may claim it’s not losing a legend but gaining a brand name. But can its new leader see past the bottom line to make amfAR not only fashionable but relevant again?”
amfAR would argue they are exceedingly relevant with their latest grants to three young scientists working on new HIV treatments and “leveraging vaccine research to help cure HIV.”
Krim does not leave this earth a saint—she disagreed with Taylor about going international, for instance, a debate Taylor won with the organization being renamed the Foundation for AIDS Research (amfAR, versus amFAR). To date amfAR has raised and invested an estimated $517 million for thousands of programs, according to the New York Times obituary on Krim.
And Taylor was not the only one with whom Krim disagreed, especially over political issues. In 1990, New York Mayor David N. Dinkins asked Krim about naming a city health commissioner. Krim recommended Indiana’s commissioner, Dr. Woodrow A. Myers Jr., who advocated names-reporting and possible quarantining of people with AIDS. Krim and others thought about it, stepped back, then re-endorsed Myers, then withdrew the endorsement. Myers was eventually appointed anyway and Krim was out in the cold.
“I think she’s exceptionally naïve politically,” playwright Larry Kramer told The Times. “We are all very angry with her, so far as one can ever get angry with Mathilde, because we love her so.”
But in 2000, Krim received the Presidential Medal of Freedom from President Clinton for her decades of AIDS-related work. And the National Portrait Gallery accepted two photographic portraits of Krim into its permanent collection in recognition of her leadership in the fight against HIV/AIDS—portraits by leading American photographers Annie Leibovitz and Joyce Tenneson.
”Everybody thinks of at least one person whom he has lost or is afraid for,” Krim told the New York Times in 1988. ”And I am no different. I have my little list.”
And now it’s Mathilde Krim who is on the list of AIDS heroes who have died.
“Dr. Krim was a close friend and mentor, and I am deeply saddened by this news. She dedicated her life to understanding the science behind the epidemic, and was a force to mobilize research around the globe that helped to save millions of lives and reduce the stigma attached to HIV/AIDS,” Elton John, Founder of the Elton John AIDS Foundation (EJAF). “The legacy of Dr. Krim’s deep commitment to ending HIV/AIDS will live on in the advocacy, action, and compassion of those that follow her lead. We would not be where we are today without her, and we must continue to work tirelessly to further understand and prevent the disease. My thoughts are with her family at this time, she was a true hero.”
“For over three decades, I have witnessed one of the most remarkable women in my lifetime fight against the plague of HIV/AIDS,” longtime LGBT rights activist/author David Mixner, who was honored by amfAR. “Dr. Krim was there when no one else would even touch us. There was not one day in the fight against this epidemic that she wasn’t working by our side. Dr. Mathilde Krim was a true legend, heroine and a dear friend.”
“We have lost an inspirational, tireless, and catalytic leader of our movement,” said Mark Harrington, Treatment Action Group’s Executive Director. “Dr. Krim understood the gravity of the epidemic, in its earliest and darkest days, and was driven by her own remarkable intelligence, fierce commitment to civil rights and social justice, extraordinary social and political networks, and true grit to galvanize funders, scientists, policy leaders, and activists toward a single cause: ending HIV and AIDS as a threat to humanity.”
“I genuinely believe that we wouldn’t be where we are today without Dr. Krim’s brilliance, determination, and mobilization,” said Tim Horn, Deputy Executive Director of HIV & HCV Programs at TAG. “Beyond her unparalleled contributions to HIV/AIDS research fundraising and awareness, she was an interminable source of strength, support, and wisdom for countless activists over the years.”
“TAG has lost a matriarch of our family, a leader in our movement, and a steadfast supporter of our work,” said Barbara Hughes, President of TAG’s Board of Directors. “We mourn Dr. Krim’s passing and join amfAR and so many leaders in the fight against HIV/AIDS in remembering her work and life.”
“Matilda Krim was a pioneering legend. Her compassion and foresight at the very beginning of the epidemic played a crucial role in mobilizing support to fight the battle against AIDS,” says Michael Weinstein, president of AIDS Healthcare Foundation.
“Even though Mathilde has been gone for a while from any active Public role, it does feel like the end of an era,” says Sean Strub, founder of POZ Magazine and out HIV-positive mayor of Milford, Pennsylvania.
“Mathilde used her resources, curiosity, tenacity and heart to provide leadership and build support to fund AIDS research at a time when few of her peers were willing to do so. The history of the epidemic is intertwined with her own; she was persistent, unflappable and prescient.”
“I became aware of Mathilde Krim around 1988, while I was working as the staff writer for the National AIDS Network, a coalition of community-based AIDS service organizations in Washington, D.C. By then Dr. Krim was already legendary in the HIV-AIDS community,” says John-Manuel Andriote, author of Victory Deferred: How AIDS Changed Gay Life in America. “It’s hard to overstate the importance of Dr. Krim and Elizabeth Taylor’s “mainstream” (and heterosexual) cachet in helping to ratchet down the fear and stigma associated with what then was a deadly new illness perceived as mainly afflicting gay men.”
“As an HIV positive man who has been living with the virus for over 13 years, I know that I would not be alive today without the efforts of Dr. Mathilde Krim,” says out New York City Council Speaker Corey Johnson. “I met her during my first trip to New York City, at age 18. Little did I know the important role she would play in my life. My thoughts and prayers go to the family and friends of Dr. Krim. Her legacy will live on in the countless lives she saved.”
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Local, national events to mark 35th annual World AIDS Day
HIV disproportionately affects certain populations. Men who have sex with men accounted for 70% of 32,100 estimated new HIV infections
WASHINGTON – UNAIDS dubbed this year’s World AIDS Day theme as “Let Communities Lead.” This is how conversations around HIV and AIDS should be structured, Duante’ Brown said, who manages two programs at NMAC — a nonprofit dedicated to working to end the AIDS epidemic. People living with HIV need to be considered the subject matter experts, he said.
“Bringing those people into the room, showing them that they have a voice and that there’s not just this group of people who are making a decision for them … is definitely the way that you go about this.”
Brown manages the ESCALATE program at NMAC, which aims to empower people to address HIV stigma, and the ELEVATE program, which is a training program for people with HIV to be more involved in the planning and delivery of the Ryan White HIV/AIDS Program, which is the largest federal program designed specifically for people with HIV.
In the United States, it’s estimated 1.2 million people are living with HIV, according to HIV.gov. About 13% are unaware they have HIV.
HIV also continues to disproportionately affect certain populations. Men who have sex with men accounted for 70% of the 32,100 estimated new HIV infections in 2021. And Black individuals accounted for 40% of the new infections that year, while only comprising 12% of the population of the United States, according to the CDC.
In 2023, stigma is a key inhibitor to ending the epidemic, Brown said. When stigma gets out of the way, there could be a day when there are no new cases of HIV transmissions, he said. To get around that stigma, people need to have meaningful and productive conversations about AIDS.
“Not treating it as taboo, making sure that we are empowering people living with HIV and AIDS to tell their stories and to be empowered to feel that it’s OK,” Brown said. “And that nothing is wrong with you.”
And there are events in the locally and nationally to recognize World AIDS Day, many of them aimed at abolishing the stigma that comes with talking about HIV.
At a national level, Janet Jackson is set to headline the World AIDS Day concert on Dec. 1 — an annual fundraiser sponsored by the AIDS Healthcare Foundation. The concert will be at the NRG Arena in Houston, and will also honor actor and activist Blair Underwood with its lifetime achievement award.
“[The concert] really is a way to commemorate World AIDS Day in a way that is both remembrance of those that we’ve lost, recognizing where we’re at, but also really celebrating and connecting the work that’s yet to be done. And having folks still leaving uplifted and elevated about what the future could hold,” said Imara Canady, AHF’s national director for communications and community engagement.
Jackson has long been an outspoken advocate for people living with HIV. Her song, “Together Again,” is a tribute to a friend she lost to AIDS, as well as a dedication to patients around the world.
The AIDS Healthcare Foundation, the largest nonprofit HIV/AIDS service organization and advocacy group, has several health care centers in the region and many across the nation and world. AHF also has a free HIV test locater online at freehivtest.net.
AIDSWatch, the electronic memorial to people lost to HIV and AIDS, will be viewable on www.AIDSWatch.org and on the City of West Hollywood’s WeHoTV broadcast and streaming channels, including Spectrum Channel 10 within West Hollywood, beginning at 12:01 a.m. on Thursday, Dec. 1, for 24 hours.
The City of West Hollywood will join STORIES: The AIDS Monument and APLA Health in a World AIDS Day event on Friday, Dec. 1. The evening will begin at 5:30 p.m. with a reception at the West Hollywood Park Aquatic and Recreation Center (ARC) Respite Deck, located at 8750 El Tovar Place.
After a short program with refreshments, attendees will descend the grand staircase of the ARC at 6:30 p.m. in a candlelight procession through West Hollywood Park and along N. Robertson, Santa Monica, and N. San Vicente Boulevards to the City’s Council Chambers/Public Meeting Room, located at 625 N. San Vicente Boulevard. There, the evening will continue with a screening of the award-winning 2023 documentary “Commitment to Life.” Doors will open at 7 p.m. and the screening will begin promptly at 7:15 p.m.
Events are free to attend and open to the public. Limited validated parking will be available at the West Hollywood Park 5-Story structure.
Advance RSVP is requested by reserving a spot on Eventbrite.
Maxine Waters criticizes House GOP over proposed cuts to HIV/AIDS programs
Calif. Democrat spoke at U.S. Conference on HIV/AIDS in D.C.
WASHINGTON — U.S. Rep. Maxine Waters (D-Calif.) on Wednesday sharply criticized House Republicans over their proposed cuts to HIV/AIDS prevention programs.
The California Democrat who represents the state’s 43rd Congressional District in a speech she delivered at the U.S. Conference on HIV/AIDS noted the House Appropriations Committee’s Fiscal Year 2024 Labor, Health, Human Services, Education and Related Agencies Appropriations Bill would cut $767 million from domestic HIV/AIDS programs.
Waters said the bill would cut funds to fight HIV/AIDS among underrepresented groups by 53 percent and “completely eliminates” funding for “Minority AIDS Initiative activities within the Substance Abuse and Mental Health Services Administration.” Waters also noted the appropriations measure “eliminates funding” for the Centers for Disease Control and Prevention’s Ending the HIV Epidemic Initiative, the Ryan White HIV/AIDS Program and community health centers.
“The cuts to the Minority AIDS Initiative will exacerbate racial disparities and the elimination of the (Ending the) HIV Epidemic Initiative,” said Waters.
Waters also criticized House Republicans for “refusing to authorize” the President’s Emergency Plan for AIDS Relief.” The California Democrat said ending PEPFAR “would endanger the lives of millions of people around the world who are living with HIV and endanger the lives of millions more who are at risk.”
“Moreover, it would compromise United States leadership on global health issues,” added Waters. “These programs used to have widespread support. It’s shameful that House Republicans are now trying to eliminate them. We cannot allow these cuts to pass. We cannot compromise. We will not give up.”
U.S. Reps. Jim Jordan (R-Ohio) and Marjorie Taylor Greene (R-Ga.) are among those who Waters criticized by name in her speech.
“I will speak truth to power. I want to use words that they will understand. Hell no! We won’t go! We are not going to give up,” said Waters. “That’s the people’s money. You can’t decide who you’re going to spend it on and not who you’re going to spend it on.”
More than 3,000 people are expected to attend the National Minority AIDS Council-organized conference that will end on Saturday. This year’s theme is “A Love Letter to Black Women.”
“We need a love letter to Black women,” said Waters. “We need it not only from this conference. We need it from our families often times. We need it from our communities. We need it from the churches that we give so much attention to and give our resources to and don’t really get it back. We need a love letter coming from all over this country for what we have suffered, for what we have endured, for the way that we have been denied and for the way that we have been ostracized.”
Waters in her speech specifically praised former Massachusetts Congressman Barney Frank and the late U.S. Sen. Ted Kennedy (D-Mass.) for their work in support of LGBTQ+ rights and efforts to combat HIV/AIDS. Waters also thanked Jewel Thais-Williams, who opened Catch One, a bar and restaurant on Pico Boulevard in Los Angeles that became a refuge for people with HIV/AIDS.
“They had nowhere to gather, nowhere to go, nowhere to be recognized as people who needed support,” said Waters.
B. Kaye Hayes, deputy assistant secretary for infectious disease in the Office of the Assistant Secretary for Health who is also the executive director of the Presidential Advisory Council on HIV/AIDS, is among those who are expected to speak at the conference. Mark S. King, an HIV/AIDS activist and blogger who published “My Fabulous Disease: Chronicles of a Gay Survivor” on Sept. 1, is scheduled to talk on Thursday.
Cal Benn contributed to this story.
American Red Cross ends ban on blood donations by gay men
Many healthy individuals who previously could not give will now be able to support their community through the gift of blood donation
WASHINGTON – The American Red Cross announced a historic change in the organization’s policies regarding blood donations by gay and bisexual men. Under this new donor screening process, all donors answer the same eligibility questions regardless of gender or sexual orientation and will be assessed for blood donation based on individual risk factors, not on sexual orientation.
This change by the Red Cross falls within the U.S. Food and Drug Administration finalized guidelines for blood donation issued this past May that will use a uniform individualized risk assessment questionnaire for respondents regardless of their sexual orientation, sex, or gender.
In a statement the Red Cross noted:
“This change means many healthy individuals who previously could not give will now be able to support their community through the gift of blood donation.
Andrew Goldstein, a cancer researcher from Los Angeles, was a regular blood donor in his younger years before the FDA’s previous policies made him ineligible to donate as a gay man. His desire to influence change compelled him to register as a participant in the FDA funded ADVANCE Study in 2021, which sought to gather data to evaluate the possibility of moving to an individual donor assessment. He is proud he was able to be part of the study that led to this change and is excited to finally be able to give blood again.
“There’s so much in the world that you can’t help with, and you sometimes have to see people going through difficult times, but something like giving blood feels like something so small that you can do, and it means a lot to me that I’ll be able to do that again,” said Andrew. Now, Andrew and many others are able to share their good health with patients in need of lifesaving transfusions.”
The FDA’s new protocols issued in May note that prospective donors who have had a new sexual partner, or more than one sexual partner in the past three months, and anal sex in the past three months, would be ineligible.
So would those who are “taking medications to treat or prevent HIV infection (e.g., antiretroviral therapy (ART), pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP),” because these drugs can delay the detection of HIV.
Blood donation rules have changed to be more inclusive! All donors will answer the same eligibility questions regardless of gender or sexual orientation, and more people can give lifesaving blood with the Red Cross while keeping the blood supply safe.— American Red Cross (@RedCross) August 7, 2023
We’ve worked for years… pic.twitter.com/htnLg3AHOm
Elton John AIDS Foundation launches ambitious new initiative
Throughout Pride Month, Sir Elton John and the co-chairs of The Rocket Fund are challenging supporters to let their #InnerElton out
NEW YORK – The Rocket Fund is the Elton John AIDS Foundation’s latest transformative $125 million campaign to redouble the fight against AIDS everywhere. Growing levels of stigmatization, marginalization, and poverty have led to high rates of HIV and low access to healthcare globally.
“For years, HIV/AIDS has caused enormous pain across the world, but I pray that soon this epidemic will be a thing of the past” said Sir Elton John. “More than 30 years after I launched the Elton John AIDS Foundation, my passion for reaching everyone, everywhere with education and compassionate care is still as strong as ever. The Rocket Fund will turbo-charge our mission and reach those most at risk from this terrible disease. Now is the time. This epidemic has gone on too long. We must all act together to see AIDS defeated in our lifetimes.”
Money from the fund will go towards supporting access to HIV prevention and treatment services, including providing access to HIV tests, antiretroviral therapies, and Pre-Exposure Prophylaxis (PrEP), according to the press release. Donatella Versace, one of the Rocket Fund’s co-chairs — alongside Furnish, Tani Austin, and David Geffen — has also pledged to match donations to the fund up to $300,000 during the month of June.
Throughout Pride Month, Sir Elton John and the co-chairs of The Rocket Fund are challenging supporters to let their #InnerElton out. Letting your #InnerElton out is about proudly expressing your authentic self, showing love for others and taking compassionate action. Supporters are encouraged to join the movement by posting photos of themselves on social media wearing their own take on Elton’s signature looks – or whatever makes them feel their true self – with the hashtag #InnerElton. Many notables are joining to let their #InnerElton out, including Dolly Parton, Michaela Jaé Rodriguez, JoJo Siwa, Heidi Klum, Smokey Robinson and more. Learn more here. The Let Your Inner Elton Out campaign was created by advertising agency Invisible Man and produced in partnership with global communications agency BCW.
The Foundation launched this critical initiative on June 5, the day in 1981 when the Centers for Disease Control released its first report on what would become the AIDS epidemic. This inaugural Rocket Day commemorates the early days of the fight against HIV/AIDS, while committing to accelerate progress towards ending AIDS for all.
“The end of the HIV/AIDS epidemic is within sight, and The Rocket Fund is the push we need to finally cross the horizon,” said David Furnish, Chairman of the Elton John AIDS Foundation. “To end AIDS, we must make targeted investments that can level the playing field, by tackling the inequalities and stigma that prevent people from accessing the care they desperately need. By joining The Rocket Fund and our mission, you can help transform the future for millions of people globally.”
“As we’ve learned through the global fight to stop COVID-19, epidemics do not recognize state borders, economic or cultural differences. If left unchecked, they only worsen with devastating impacts on the most vulnerable,” said Anne Aslett, Chief Executive Officer of the Elton John AIDS Foundation. “It is critical that we meet this moment to connect vulnerable people with the care and resources they need to live vibrant, healthy lives and we welcome all who want to see an end to this disease to join us.”
New data shows HIV infections dropped- mostly among whites
Significant decline in new HIV infections, but impact of prevention efforts far less substantial for Black and Hispanic-Latino populations
ATLANTA – Data published Tuesday. by the Centers for Disease Control and Prevention shows a significant decline in new HIV infections, but suggests the impact of prevention efforts was far less substantial for Black and Latino populations.
From 2017 to 2021, as rates of HIV testing, treatment, and the use of pre-exposure prophylaxis (PrEP) medication rose, new cases dropped by 12 percent overall and by as much as 34 percent among gay and bisexual males aged 13 to 24.
The numbers show a “move in the right direction,” CDC Director Rochelle Walensky said in a press release.
However, when broken down by race, the CDC found new infections were down by 27 percent and 36 percent, respectively, among Black and Hispanic-Latino populations, compared with 45 percent of whites.
Similarly, by 2021 about one third of those who are considered eligible were taking PrEP for HIV prevention, but the CDC noted this number includes “relatively few Black people or Hispanic/Latino people” despite the significant increase in prescriptions up from just 13 percent in 2017.
“Longstanding factors, such as systemic inequities, social and economic marginalization and residential segregation,” Walensky noted, continue to act as barriers “between highly effective HIV treatment and prevention and people who could benefit from them.”
She added, “Efforts must be accelerated and strengthened for progress to reach all groups faster and equitably.”
Robyn Neblett Fanfair, acting director of the CDC’s Division of HIV Prevention, said that “At least three people in the U.S. get HIV every hour—at a time when we have more effective prevention and treatment options than ever before.”
“These tools must reach deep into communities and be delivered faster to expand progress from some groups to all groups,” she said.
The HIV+Hepatitis Policy Institute issued a press release following the CDC’s announcement of the new data, noting both the encouraging progress and need for improvement.
“It appears that our investments in HIV prevention are providing some positive results, but the persistent high number of new diagnoses and the low usage of PrEP among the communities most impacted by HIV point to the need for increased resources, particularly for a national PrEP program,” said the group’s executive director, Carl Schmid.
President Joe Biden’s FY24 budget requested $237 million for a national PrEP program along with $850 million to support the U.S. Department of Health and Human Services’ “Ending the HIV Epidemic in the U.S.” initiative.
President’s Emergency Plan for AIDS Relief marks year 20
Achievements PEPFAR have been remarkable, well-documented by outside evaluators, and hugely applauded throughout the advocacy community
WASHINGTON – The President’s Emergency Plan for AIDS Relief (PEPFAR) marks its twenty year anniversary today, marking the largest commitment by any nation to address a single disease in the world.
The initiative which was personally led and launched by former President George W. Bush in 2003, its funding has totaled more than $110 billion to date, including funding for the Global Fund to Fight AIDS, Tuberculosis and Malaria (Global Fund), to which the U.S. government is the largest donor.
PEPFAR is credited with saving millions of lives and helping to change the trajectory of the global HIV epidemic. The White House today released a statement by President Joe Biden marking the 20th Anniversary:
Twenty years ago today, President George W. Bush declared that preventing and treating HIV/AIDS was a foreign policy priority of the United States. At a time when nearly 30 million people were HIV positive, but very few were receiving life-saving medicines, the President’s Emergency Plan for AIDS Relief (PEPFAR) transformed the global AIDS response and laid a marker for America’s commitment to countries that were impacted the hardest by the AIDS epidemic. Helping lead the bipartisan effort in Congress to authorize PEPFAR is among my proudest achievements from my time in the Senate. To this day, PEPFAR remains a powerful example of America’s unmatched ability to drive progress and make life better for people around the world.
Since 2003, PEPFAR has saved more than 25 million lives and dramatically improved health outcomes in more than 55 partner countries. AIDS-related deaths have declined by 68 percent since their peak in 2004, and new HIV infections are down 42 percent. PEPFAR investments have ensured that 5.5 million babies have been born HIV-free. And two decades of investment in partner nations’ health systems played a critical role in countries’ ability to respond to other health crises such as COVID-19, Mpox, and Ebola.
Today, PEPFAR continues to support 20.1 million people around the world with HIV/AIDS treatment, and my Administration is committed to continuing to lead the global HIV/AIDS response. We will build on our decades of progress to reach the Sustainable Development Goal of ending AIDS by 2030, work to eliminate the stigma and inequities that keep people from accessing care, and keep the voices of people living with HIV/AIDS at the center of our response. I look forward to working with Congress on PEPFAR’s reauthorization this year.
PEPFAR is overseen by the U.S. Global AIDS Coordinator, who is appointed by the President, confirmed by the Senate, and reports directly to the Secretary of State, as established through PEPFAR’s authorizing legislation.
PEPFAR’s original authorization established new structures and authorities, consolidating all U.S. bilateral and multilateral activities and funding for global HIV/AIDS. Several U.S. agencies, host country governments, and other organizations are involved in implementation.
Dr. John Nkengasong, the current coordinator was sworn in on June 13, 2022, and holds the rank of Ambassador leading the Office of the Global AIDS Coordinator (OGAC) at the U.S. Department of State.
Twenty years ago this month, President George W. Bush announced #PEPFAR during his State of the Union address. Since then, the U.S. government has invested $100B+ in the global HIV/AIDS response through PEPFAR, saving 25M lives & bringing us closer to #EndAIDS2030. #PEPFAR20 pic.twitter.com/SMAOHWPZ03— PEPFAR (@PEPFAR) January 11, 2023
Nobel Prize winning scientist Harold Varmus, who served as Director of the National Institutes of Health (NIH) from 1993 to 1999 and currently the Lewis Thomas University Professor of Medicine at Weill Cornell Medicine in New York City, wrote in an article honoring World Aids Day 2013:
[…] “the PEPFAR story must begin with George W. Bush and his wife, Laura, and their interests in AIDS, Africa, and what Bush termed “compassionate conservatism.” According to his 2010 memoir, Decision Points, the two of them developed a serious interest in improving the fate of the people of Africa after reading Alex Haley’s Roots and visiting The Gambia in 1990.3 In 1998, while pondering a run for the U.S. presidency, he discussed Africa with Condoleezza Rice, his future secretary of state; she said that, if elected, working more closely with countries on that continent should be a significant part of his foreign policy. She also told him that HIV/AIDS was a central problem in Africa but that the United States was spending only $500 million per year on global AIDS, with the money spread across six federal agencies, without a clear strategy for curbing the epidemic.”
Key Facts (As provided by Kaiser Health & Family Foundation)
- Although the U.S. has been involved in efforts to address the global AIDS crisis since the mid-1980s, the creation of the President’s Emergency Plan for AIDS Relief (PEPFAR) in 2003 marked a significant increase in funding and attention to the epidemic.
- PEPFAR is the largest commitment by any nation to address a single disease in the world; to date, its funding has totaled more than $110 billion, including funding for the Global Fund to Fight AIDS, Tuberculosis and Malaria (Global Fund), to which the U.S. government is the largest donor. PEPFAR is credited with saving millions of lives and helping to change the trajectory of the global HIV epidemic.
- U.S. funding for PEPFAR grew from $2.2 billion in FY 2004 to $7.0 billion in FY 2022; FY 2022 funding includes $5.4 billion provided for bilateral HIV efforts and $1.6 billion for multilateral efforts ($50 million for UNAIDS and $1.56 billion for the Global Fund).
- As the COVID-19 pandemic continues to have profound effects across the world, PEPFAR has acted to respond to COVID-19 in countries that receive support in order to minimize HIV service disruptions and leverage the program’s capabilities to address COVID-19 more broadly.
- Looking ahead, PEPFAR faces several issues and challenges, including how best to: address the short- and long-term impacts of COVID-19 on PEPFAR and the HIV response; accelerate progress toward epidemic control in the context of flat funding; support and strengthen community-led responses and the sustainability of HIV programs; define its role in global health security and broader health systems strengthening efforts; and continue to coordinate with other key players in the HIV ecosystem, including the Global Fund.
Key Activities and Results (As provided by Kaiser Health & Family Foundation)
PEPFAR activities focus on expanding access to HIV prevention, treatment, and care interventions. These include provision of antiretroviral treatment, pre-exposure prophylaxis, voluntary male circumcision, condoms, and other commodities related to HIV services. In addition, PEPFAR has launched specific initiatives in key strategic areas. For example, in 2015, PEPFAR launched DREAMS, a public-private partnership that aims to reduce HIV infections in adolescent girls and young women.
The latest results reported by PEPFAR indicate that it has:
- supported testing services for 63.4 million people in FY 2021;
- prevented 2.8 million babies from being born with HIV, who would have otherwise been infected;
- provided care for more than 7.1 million orphans and vulnerable children (OVC);
- supported training for nearly 300,000 new health care workers; and
- supported antiretroviral treatment for 18.96 million people.
- In the 15 countries implementing the DREAMS initiative, new diagnoses among adolescent girls and young women have declined with most DREAMS areas (96%) experiencing declines greater than 25% and nearly two-thirds with declines greater than 40%.
The achievements of the PEPFAR program have been remarkable, well-documented by outside evaluators, and hugely applauded throughout the advocacy community and the developing world. In general, milestones have been met, the program has been enlarged (for instance, to include some research on implementation of medical assistance), the roster of PEPFAR countries has grown and spending plans have not been exceeded.
FDA eases blood donation restrictions for gay & bisexual men
The FDA’s proposal would lift the mandatory three-month deferral period for some men who have sex with men
SILVER SPRING, Md. – The U.S. Food and Drug Administration (FDA) introduced a proposed change to its blood donation guidelines on Friday that would ease restrictions for gay and bisexual men.
The FDA notes the proposal, news of which was first reported in November, would bring U.S. policies in alignment with those in place in countries like the U.K. and Canada. The agency is expected to formally adopt the new guidelines after a public comment period.
The move follows criticism from LGBTQ groups and organizations like the American Medical Association (AMA) who have long argued the current policy is homophobic and based on an outdated understanding of the risks associated with blood donation by men who have sex with men.
As the AMA wrote of the current policy: “a man who has protected sex with another man in the three months prior to a blood donation cannot be a donor, but a man or woman who has unprotected sex with multiple partners of the opposite sex over the same time period remains eligible.”
The FDA’s proposal would lift the mandatory three-month deferral period for some men who have sex with men and instead use a “gender-inclusive, individual risk-based questions relevant to HIV risk.”
Potential donors would be asked for information about their sexual history over the past three months. Respondents who indicate they have had sex with one or more new sexual partners would then be asked whether they have had anal sex during this period. Those who answer “yes” would be deferred from blood donation.
Axios noted that as of this morning, about 20 percent of the country’s community blood centers have a one-day supply or less, while the FDA’s broadened eligibility criteria would increase the annual blood supply by two to four percent, citing data from America’s Blood Centers’ daily tracker and the Williams Institute.
U.S. Sen. Tammy Baldwin (D-Wis.) issued a statement celebrating the FDA’s proposal. “As I have long advocated for, this blood donation policy takes a step forward and is better rooted in the most up-to-date science with a focus on individual risk factors, not outdated stigmas that effectively ban gay and bisexual men,” she said.
Baldwin has repeatedly urged the agency to revisit its blood donation policy over the years, including by corralling support from other members of Congress to cosign letters to the FDA in 2014 and 2016, raising the issue again in 2020 as the COVID-19 pandemic exacerbated shortages in the blood supply.
The Congressional LGBTQ+ Equality Caucus also acknowledged the move in a statement by its chair, Rep. Mark Pocan (D-Wis.): “I am glad the FDA is finally moving toward an individual risk-based assessment model, but recognize, based on existing reporting, that many LGBTQI+ people may still be barred from donating,” he said. “I look forward to taking a closer look at the proposed guidelines once they are published and working with the FDA to ensure that any unnecessary barriers are removed.”
Several LGBTQ groups also issued statements celebrating the FDA’s new guidance.
“These changes are 40-plus years in the making, and are a tremendous leap forward toward elevating science over stigma,” said GLAAD President Sarah Kate Ellis. “GLAAD and leading medical experts have long been advocating for guidelines that see and treat LGBTQ people the same as any other person, including as potential donors who want to help others.”
“This new policy removes a decades-long barrier for many in our community – and there is more to do to ensure gay, bisexual and transgender people are no longer unfairly stigmatized when they try to donate blood,” Human Rights Campaign President Kelley Robinson said. “The assessment criteria have flaws, focusing excessively, for instance, on the number of partners a potential donor has instead of just on new partners,” she added.
Carl Schmid, executive director of the HIV+ Hepatitis Policy Institute, said: “While this long-overdue change is being made based on the science and the facts, which have been clear for years, it is the result of the leadership of the Biden administration that continues to tear down discriminatory government policies.”
Experimental HIV vaccine failure, deemed safe but ineffective
“We remain steadfast in our commitment to advancing innovation in HIV & hope the data from Mosaico will provide insights for future efforts”
BETHESDA, Md. – A clinical trial of an investigational HIV vaccine regimen, being conducted in partnership with the National Institute of Allergy and Infectious Diseases (NIAID) by Janssen Pharmaceutical Companies and global partners of parent company Johnson & Johnson dubbed “Mosaico,” was discontinued.
In an announcement made Wednesday, NIAID said the HIV vaccine regimen tested among men who have sex with men (MSM) and transgender people was safe but did not provide protection against HIV acquisition, an independent data and safety monitoring board had determined.
A spokesperson for Johnson & Johnson noted in light of the board’s determination, the Mosaico clinical trial will be discontinued. Participant notifications and further analyses of the data are underway. Throughout the trial, study investigators have ensured that any individuals who contracted HIV received prompt HIV treatment and care.
Both Johnson & Johnson and NIAID stressed that no safety issues with the vaccine regimen were identified.
“We are disappointed with this outcome and stand in solidarity with the people and communities vulnerable to and affected by HIV,” said Penny Heaton, M.D., Global Therapeutic Area Head, Vaccines, Janssen Research & Development, LLC. “Though there have been significant advances in prevention since the beginning of the global epidemic, 1.5 million people acquired HIV in 2021 alone, underscoring the high unmet need for new options and why we have long worked to tackle this global health challenge. We remain steadfast in our commitment to advancing innovation in HIV, and we hope the data from Mosaico will provide insights for future efforts to develop a safe and effective vaccine. We are grateful to our Mosaico partners and the study investigators, staff and participants.”
Janssen Vaccines & Prevention sponsored the Mosaico study with funding support from NIAID, part of the National Institutes of Health. The trial was conducted by the NIAID-funded HIV Vaccine Clinical Trials Network, based at the Fred Hutchinson Cancer Research Center in Seattle. The U.S. Army Medical Research and Development Command provided additional study support.
The Phase 3 Mosaico Study:
Mosaico, a Phase 3 study of Janssen’s investigational HIV vaccine regimen, began in 2019, and completed vaccinations in October 2022. The study included approximately 3,900 cisgender men and transgender people who have sex with cisgender men and/or transgender people, who represent groups and populations vulnerable to HIV, at over 50 trial sites in Argentina, Brazil, Italy, Mexico, Peru, Poland, Puerto Rico, Spain and the United States.
The study evaluated an investigational vaccine regimen containing a mosaic-based adenovirus serotype 26 vector (Ad26.Mos4.HIV) administered during four vaccination visits over one year. A mix of soluble proteins (Clade C/Mosaic gp140, adjuvanted with aluminum phosphate) was also administered at visits three and four.
The Mosaico DSMB analysis, based on the data available to date, indicated that the regimen does not protect against HIV and the study is not expected to meet its primary endpoint. No safety issues with the vaccine regimen were identified. In light of this, the study will be discontinued, and further analyses are underway.
Patti LaBelle, Gladys Knight dazzle World AIDS Day concert
“As millions remain affected by HIV/AIDS, World AIDS Day provides an opportunity to honor those we’ve lost and those living with HIV/AIDS”
WASHINGTON – The AIDS Healthcare Foundation (AHF) hosted its 2022 World AIDS Day Concert on Wednesday, Nov. 30, in the concert hall of The John F. Kennedy Center for the Performing Arts in the nation’s capital.
Renowned multi-Grammy Award-winning vocalists Patti LaBelle and Gladys Knight delivered show-stopping performances to the packed crowd, which included supporters, dignitaries such as: Harold Phillips, Director of the White House Office of National AIDS Policy; White House Senior Advisor for Public Engagement, Mayor Keisha Lance Bottoms, Congresswoman Sheila Jackson Lee, and New Orleans Mayor, Mayor LaToya Cantrell, and more, in a night of hope and celebration.
AIDS Healthcare Foundation (AHF), is the world’s largest HIV/AIDS care provider, currently operating in 45 countries. The concert is held every year to commemorate World AIDS Day, observed internationally each year on Dec. 1. This year also marked the global organization’s 35th anniversary.
At the event, longtime humanitarian and AIDS advocate, Princess Diana was honored, posthumously, with AHF’s Lifetime Achievement Award. Under its “Keep the Promise!” banner, AHF also acknowledged progress made in the global fight against HIV and AIDS and continues to raise awareness about “The Other Pandemic” as a reminder of the significant work still to be done on HIV/AIDS, as well as remembering the lives that have been lost over the years.
Michael Weinstein, President of AHF, said, “As millions remain affected by HIV/AIDS around the globe, World AIDS Day annually provides an opportunity to honor those we’ve lost and those living with HIV/AIDS today, as well as reminding leaders and the community of the work that still remains to address this epidemic. From providing compassionate AIDS hospice care in those darkest early days to growing to become the largest global AIDS organization today, now providing lifesaving care and treatment to more than 1.7 million people around the globe, we also celebrate the tireless work of all those who help make today’s AHF possible: our staff, Board, affiliate organizations and affinity groups, friends, family and elected officials and community partners across the globe, but most of all, our clients and patients—with our annual 2022 World AIDS Day event. It was a momentous night to host our World AIDS Day concert at The Kennedy Center for the first time, and welcome back the legendary Patti LaBelle, and have another great American icon, Gladys Knight join us, while also being able to honor the legacy and humanitarian work of the late Princess Diana.”
Cleve Jones, activist & founder of AIDS Memorial Quilt honored
National AIDS Memorial hosted observances at the 10-acre Memorial Grove and displaying Quilt in nearly 100 communities throughout the U.S.
SAN FRANCISCO – The National AIDS Memorial marked World AIDS Day with a national observance at the 10-acre National AIDS Memorial Grove in San Francisco, honoring AIDS activist and founder of the AIDS Memorial Quilt Cleve Jones with its Lifetime of Commitment Award.
The two days of events brought together leaders on the front lines of the epidemic for powerful conversations and events focused on “Changing the Pattern for a Future without AIDS,” referencing a major initiative of the Memorial that is bringing the Quilt to the South to address the growing crisis of rising HIV rates amount communities of color and marginalized populations.
Jones, who founded the Quilt thirty-five years ago, was recognized for his visionary leadership, activism, and powerful voice in the fight for health and social justice. He remains an inspirational force for change and action today, standing up without hesitation and using his voice for those who are often overshadowed and not heard.
U.S. House Speaker, Rep. Nancy Pelosi (D-Cailf.) praised Jones in a special video tribute, saying, “Cleve, you are a force of nature – unshakable in the face of adversity, overflowing with a passion for serving others.”
“When the AIDS crisis tightened its grip on San Francisco – when pain and despair grew rampant – you kept hope alive,” she continued. “You were a shining light in the dark, building community out of grief and spurring action out of anguish. From the halls of power to union halls and picket lines, you have never relented in your mission: empowering the oppressed, tearing down injustice and honoring the dignity and beauty of every person.”
Presenting the award to Jones was former San Francisco mayor and mentor Art Agnos to an audience of more than 600 people from the community who gathered on the eve of World AIDS Day for a gala to support the Memorial’s programs.
“I’m honored to receive this award, but more importantly I’m so pleased that the Quilt now has a permanent home with the National AIDS Memorial and that it is continuing its mission of activism and justice. One thing I’ve learned is that through hope one finds courage and through courage we find love. Love is at the core of what we do and that is what this Quilt represents,” Jones told the audience gathered.
The National AIDS Memorial worked with local partners from across the country to display hundreds of Quilt sections featuring more than 3,500 individual panels in nearly 100 communities on World AIDS Day.
The largest Quilt display ever in Alabama is taking place in Montgomery and surrounding areas as part of the memorial’s Change the Pattern initiative. The program, funded through a $2.4 million grant from Gilead Sciences, is organizing quilting workshops, displays and educational programming with Southern AIDS Coalition throughout the Southern U.S.
“On this World AIDS Day, it is inspiring to know that thousands of Quilt panels are on display in communities across the country, touching hearts and minds through the stories represented in the fabric,” said Gilead Sciences Chairman and CEO Daniel O’Day. “The Quilt’s purpose remains as strong and important today, as it was thirty-five years ago, when the vision of Cleve Jones sparked a powerful movement to advance health and social justice.”
The National AIDS Memorial’s World AIDS Day Observance panelists highlighted the importance of the work being done around the country, the interconnectivity of issues to reach zero, and the importance of education and outreach to at-risk populations during three powerful conversations available for viewing online on the memorial’s website and include: Reflections with Cleve Jones and 35 years of the Quilt; The State of the Epidemic Today with Leaders on the Frontlines; and Young Leaders Making an Impact.
“As our community comes together this World AIDS Day, it’s hard not to look around and see who’s missing – our friends, lovers, and family we’ve lost over four decades of this horrific, cruel disease,” said National AIDS Memorial CEO John Cunningham. “It always brings tears, and we carry so many emotions, particularly as we think of what could have been. But for me, as a man living with HIV/AIDS, I shift to a brighter space, choosing to look around me, thinking about so many of us still here, living and thriving. Survivors, who have so much to be thankful for, but also a heavy burden to share our own stories and journey, so history never repeats itself.”
He continued, “Today, people are still dying and there should have been a cure long ago. We are angry because bigotry, hate, and stigma persist today in society. And we carry shame, because communities of color and marginalized populations continue to be disproportionately impacted by HIV and discrimination, and it shouldn’t be this way. It’s time to change the pattern.”
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